Pub. Date : 2003 Aug 15
PMID : 12960109
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The homozygous T allele of the ABCB1 1236C>T polymorphism was associated with significantly increased exposure to irinotecan (P = 0.038) and its active metabolite SN-38 (P = 0.031). | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The homozygous T allele of the ABCB1 1236C>T polymorphism was associated with significantly increased exposure to irinotecan (P = 0.038) and its active metabolite SN-38 (P = 0.031). | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSIONS: It is concluded that genotyping for ABCB1 1236C>T may be one of the factors assisting with dose optimization of irinotecan chemotherapy in cancer patients. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |