PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12960109-5 2003 The homozygous T allele of the ABCB1 1236C>T polymorphism was associated with significantly increased exposure to irinotecan (P = 0.038) and its active metabolite SN-38 (P = 0.031). Irinotecan 117-127 ATP binding cassette subfamily B member 1 Homo sapiens 31-36 12960109-5 2003 The homozygous T allele of the ABCB1 1236C>T polymorphism was associated with significantly increased exposure to irinotecan (P = 0.038) and its active metabolite SN-38 (P = 0.031). Irinotecan 166-171 ATP binding cassette subfamily B member 1 Homo sapiens 31-36 12960109-8 2003 CONCLUSIONS: It is concluded that genotyping for ABCB1 1236C>T may be one of the factors assisting with dose optimization of irinotecan chemotherapy in cancer patients. Irinotecan 128-138 ATP binding cassette subfamily B member 1 Homo sapiens 49-54