Title : NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons.

Pub. Date : 2003 Sep 26

PMID : 12842875






2 Functional Relationships(s)
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1 Nrf2-/- neurons in this mixed culture system were more sensitive to mitochondrial toxin (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine or rotenone)-induced apoptosis compared with Nrf2+/+ neurons. Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens
2 Finally, adenoviral vector-mediated overexpression of Nrf2 recovered ARE-driven gene expression in Nrf2-/- neuronal cultures and rescued Nrf2-/- neurons from rotenone- or ionomycin-induced cell death. Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens