Title : PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.

Pub. Date : 2003 Jul 1

PMID : 12839945






1 Functional Relationships(s)
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Protein Name
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1 PTEN and LY294002 induced p53 activity in human brain endothelial cells, suggesting that PTEN and PI3K pathways can suppress the progression of cancer through direct actions on tumor and endothelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one phosphatase and tensin homolog Homo sapiens