Pub. Date : 2003 Sep 5
PMID : 12824177
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exposure of bovine aortic endothelial cells (BAEC) to chemically synthesized ONOO- acutely and significantly increased phosphorylation of c-Src, PDK1, AMPK, and its downstream target, acetyl-CoA carboxylase (ACC), without affecting cellular AMP. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | Moreover, H/R, like ONOO-, significantly increased co-immunoprecipitation of AMPK with c-Src, suggesting that ONOO- favors physical association of AMPK with upstream kinases. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | Moreover, H/R, like ONOO-, significantly increased co-immunoprecipitation of AMPK with c-Src, suggesting that ONOO- favors physical association of AMPK with upstream kinases. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | Moreover, H/R, like ONOO-, significantly increased co-immunoprecipitation of AMPK with c-Src, suggesting that ONOO- favors physical association of AMPK with upstream kinases. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 5 | Moreover, H/R, like ONOO-, significantly increased co-immunoprecipitation of AMPK with c-Src, suggesting that ONOO- favors physical association of AMPK with upstream kinases. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 6 | Taken together, our results indicate a novel pathway by which H/R via ONOO- activates AMPK in a c-Src-mediated, PI 3-kinase-dependent manner, and suggest that ONOO--induced activation of AMPK might thereby regulate metabolic enzymes, such as ACC. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 7 | Taken together, our results indicate a novel pathway by which H/R via ONOO- activates AMPK in a c-Src-mediated, PI 3-kinase-dependent manner, and suggest that ONOO--induced activation of AMPK might thereby regulate metabolic enzymes, such as ACC. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 8 | Taken together, our results indicate a novel pathway by which H/R via ONOO- activates AMPK in a c-Src-mediated, PI 3-kinase-dependent manner, and suggest that ONOO--induced activation of AMPK might thereby regulate metabolic enzymes, such as ACC. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 9 | Taken together, our results indicate a novel pathway by which H/R via ONOO- activates AMPK in a c-Src-mediated, PI 3-kinase-dependent manner, and suggest that ONOO--induced activation of AMPK might thereby regulate metabolic enzymes, such as ACC. | onoo | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |