Pub. Date : 2003 Jun
PMID : 12790799
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | PMA-mediated activation of PKC (100 nM; 4 h) reduced glucose/IGF-I mediated beta-cell mitogenesis (>50%; P< or =0.05), which was reversible by the general PKC inhibitor Go6850 (1 microM), indicating an effect of PKC and not due to a non-specific PMA toxicity. | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Rattus norvegicus |
2 | Thus, FFA/PMA-induced activation of novel PKC isoforms can inhibit glucose/IGF-I-mediated beta-cell mitogenesis, in part by decreasing PKB activation, despite an upregulation of Erk1/2. | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Rattus norvegicus |