Title : Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).

Pub. Date : 2003 Jun

PMID : 12790799






2 Functional Relationships(s)
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1 PMA-mediated activation of PKC (100 nM; 4 h) reduced glucose/IGF-I mediated beta-cell mitogenesis (>50%; P< or =0.05), which was reversible by the general PKC inhibitor Go6850 (1 microM), indicating an effect of PKC and not due to a non-specific PMA toxicity. Tetradecanoylphorbol Acetate insulin-like growth factor 1 Rattus norvegicus
2 Thus, FFA/PMA-induced activation of novel PKC isoforms can inhibit glucose/IGF-I-mediated beta-cell mitogenesis, in part by decreasing PKB activation, despite an upregulation of Erk1/2. Tetradecanoylphorbol Acetate insulin-like growth factor 1 Rattus norvegicus