Title : Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities.

Pub. Date : 2003 Jul 18

PMID : 12734187






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GH stimulated the tyrosine phosphorylation of C3G, which again required the combined activity of JAK2 and c-Src. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus
2 C3G tyrosine residue 504 was required for GH-stimulated Rap activation. Tyrosine Rap guanine nucleotide exchange factor (GEF) 1 Mus musculus