Title : Induction of hepatic cytochrome P450s responsible for the metabolism of xenobiotics by nicardipine and other calcium channel antagonists in the male rat.

Pub. Date : 2003 Feb

PMID : 12623755






1 Functional Relationships(s)
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1 We have demonstrated for the first time that nicardipine activated not only the genes of CYP2B1, CYP2B2, CYP3A1 and CYP3A2, but also those of CYP1A1 and CYP1A2 in the rat liver and have further suggested that calcium channel antagonists may show a common capacity for activating the genes of CYP2B1, CYP2B2, CYP3A1 and CYP3A2. Nicardipine cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus