Title : Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta.

Pub. Date : 2002 Dec 5

PMID : 12531010






2 Functional Relationships(s)
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1 DNA polymerases beta (pol beta ) and eta (pol eta ) are the only two eukaryotic polymerases known to efficiently bypass cisplatin and oxaliplatin adducts in vitro. Oxaliplatin DNA polymerase beta Homo sapiens
2 We have compared the types of frameshifts that occur during translesion synthesis past cisplatin and oxaliplatin adducts in vitro by pol beta and pol eta on a template containing multiple runs of nucleotides flanking a single platinum-GG adduct. Oxaliplatin DNA polymerase beta Homo sapiens