Protein Name DNA polymerase beta
Organism Homo sapiens
Gene ID 5423
Gene Symbol

POLB

UniProt P06746 (DPOLB_HUMAN), B7Z1W5 (B7Z1W5_HUMAN)
Relationships Total Number of functionally related compound(s) : 414
Total Number of Articles : 463
Description

DNA polymerase beta

Gene Summary

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]

synonyms
  • DNA polymerase beta
  • 5'-dRP lyase
  • 5'-deoxyribose-phosphate lyase
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Properties