Title : Desnitro-imidacloprid activates the extracellular signal-regulated kinase cascade via the nicotinic receptor and intracellular calcium mobilization in N1E-115 cells.

Pub. Date : 2002 Nov 1

PMID : 12460746






3 Functional Relationships(s)
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1 The excellent safety profile of IMI is not shared with a metabolite, desnitro-IMI (DNIMI), which displays high toxicity to mammals associated with agonist action at the alpha4beta2 nicotinic acetylcholine receptor (nAChR) in brain. desnitroimidacloprid cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The excellent safety profile of IMI is not shared with a metabolite, desnitro-IMI (DNIMI), which displays high toxicity to mammals associated with agonist action at the alpha4beta2 nicotinic acetylcholine receptor (nAChR) in brain. desnitroimidacloprid cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 This study examines the hypothesis that IMI, DNIMI, and (-)-nicotine activate the extracellular signal-regulated kinase (ERK) cascade via primary interaction with the alpha4beta2 nAChR in mouse neuroblastoma N1E-115 cells. desnitroimidacloprid cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus