PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12460746-2 2002 The excellent safety profile of IMI is not shared with a metabolite, desnitro-IMI (DNIMI), which displays high toxicity to mammals associated with agonist action at the alpha4beta2 nicotinic acetylcholine receptor (nAChR) in brain. desnitroimidacloprid 69-81 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 215-220 12460746-2 2002 The excellent safety profile of IMI is not shared with a metabolite, desnitro-IMI (DNIMI), which displays high toxicity to mammals associated with agonist action at the alpha4beta2 nicotinic acetylcholine receptor (nAChR) in brain. desnitroimidacloprid 83-88 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 215-220 12460746-3 2002 This study examines the hypothesis that IMI, DNIMI, and (-)-nicotine activate the extracellular signal-regulated kinase (ERK) cascade via primary interaction with the alpha4beta2 nAChR in mouse neuroblastoma N1E-115 cells. desnitroimidacloprid 45-50 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 179-184