Title : Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.

Pub. Date : 2002 Dec

PMID : 12438513






5 Functional Relationships(s)
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1 Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
2 In this study, we tested the hypothesis that CYP1A2, a liver-specific P450 isozyme, plays an important role in the mechanisms governing persistent CYP1A1 induction by MC in liver but not in extra-hepatic tissues such as lung, which is devoid of endogenous CYP1A2. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
3 Administration of wild-type (WT) or CYP1A2-null mice with MC (100 micromol/kg i.p.) Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
4 Since MC is almost completely eliminated by day 15, we hypothesize that CYP1A2 contributes to the up-regulation of CYP1A1 in liver, but not lung, by a novel mechanism, presumably involving a CYP1A2-dependent persistent metabolite. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus
5 Since MC is almost completely eliminated by day 15, we hypothesize that CYP1A2 contributes to the up-regulation of CYP1A1 in liver, but not lung, by a novel mechanism, presumably involving a CYP1A2-dependent persistent metabolite. Methylcholanthrene cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus