PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12438513-0	2002	Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.	Methylcholanthrene	92-112	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	133-139	
12438513-3	2002	In this study, we tested the hypothesis that CYP1A2, a liver-specific P450 isozyme, plays an important role in the mechanisms governing persistent CYP1A1 induction by MC in liver but not in extra-hepatic tissues such as lung, which is devoid of endogenous CYP1A2.	Methylcholanthrene	167-169	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	45-51	
12438513-4	2002	Administration of wild-type (WT) or CYP1A2-null mice with MC (100 micromol/kg i.p.)	Methylcholanthrene	58-60	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	36-42	
12438513-8	2002	Since MC is almost completely eliminated by day 15, we hypothesize that CYP1A2 contributes to the up-regulation of CYP1A1 in liver, but not lung, by a novel mechanism, presumably involving a CYP1A2-dependent persistent metabolite.	Methylcholanthrene	6-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	72-78	
12438513-8	2002	Since MC is almost completely eliminated by day 15, we hypothesize that CYP1A2 contributes to the up-regulation of CYP1A1 in liver, but not lung, by a novel mechanism, presumably involving a CYP1A2-dependent persistent metabolite.	Methylcholanthrene	6-8	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	191-197