Title : Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain.

Pub. Date : 2002 Dec

PMID : 12438507






2 Functional Relationships(s)
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1 Nicotine elicited a dose-dependent elevation of mRNA for tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine biosynthesis in VTA and SN. Nicotine tyrosine hydroxylase Rattus norvegicus
2 The findings indicate that nicotine may regulate dopamine biosynthesis by alterations in gene expression of TH and its cofactor. Nicotine tyrosine hydroxylase Rattus norvegicus