Title : A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571.

Pub. Date : 2003 Feb 14

PMID : 12435730






1 Functional Relationships(s)
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1 Courses of the activation loop that collide with STI-571 binding explain its inactivity at other kinases as the insulin receptor. Imatinib Mesylate insulin receptor Homo sapiens