Pub. Date : 2002 Nov
PMID : 12390318
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ribavirin increases mitogen- and antigen-induced expression of CD40L on CD4+ T cells in vivo. | Ribavirin | CD4 molecule | Homo sapiens |
| 2 | In contrast, after stimulation with both HCV core antigen and phorbol myristate acetate (PMA) plus ionomycin (IO), the expression of CD40L on CD4 lymphocytes was significantly higher in the ribavirin group compared with controls. | Ribavirin | CD4 molecule | Homo sapiens |
| 3 | In conclusion, these data indicate that ribavirin -upmodulates CD40L expression on CD4 T cells, a property which may account in part for its ability to enhance the antiviral activity of interferon-alpha in the treatment of chronic HCV infection. | Ribavirin | CD4 molecule | Homo sapiens |