Pub. Date : 2002 Oct 15
PMID : 12369824
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While GTPase-defective forms of Cdc42 inhibit cell growth, a mutation [Cdc42(F28L)] that allows the constitutive exchange of GDP for GTP and is GTPase-competent induces cellular transformation. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 2 | These results suggest that Cdc42 must cycle between its GTP- and GDP-bound states to stimulate cell growth. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 3 | The Cdc42(D118N) protein exchanges GDP for GTP more rapidly than wild-type Cdc42, but significantly more slowly than the Cdc42(F28L) mutant. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 4 | Thus, mutations that combine some capacity for cycling between the GTP- and GDP-bound states with increased survival against apoptotic signals yield Cdc42 molecules with the maximum capability for inducing cellular transformation. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |