PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12369824-2	2002	While GTPase-defective forms of Cdc42 inhibit cell growth, a mutation [Cdc42(F28L)] that allows the constitutive exchange of GDP for GTP and is GTPase-competent induces cellular transformation.	Guanosine Diphosphate	125-128	cell division cycle 42	Homo sapiens	71-76	
12369824-3	2002	These results suggest that Cdc42 must cycle between its GTP- and GDP-bound states to stimulate cell growth.	Guanosine Diphosphate	65-68	cell division cycle 42	Homo sapiens	27-32	
12369824-6	2002	The Cdc42(D118N) protein exchanges GDP for GTP more rapidly than wild-type Cdc42, but significantly more slowly than the Cdc42(F28L) mutant.	Guanosine Diphosphate	35-38	cell division cycle 42	Homo sapiens	4-9	
12369824-10	2002	Thus, mutations that combine some capacity for cycling between the GTP- and GDP-bound states with increased survival against apoptotic signals yield Cdc42 molecules with the maximum capability for inducing cellular transformation.	Guanosine Diphosphate	76-79	cell division cycle 42	Homo sapiens	149-154