Pub. Date : 2002 Sep-Oct
PMID : 12359143
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, by using a radiolabeled cholesterol efflux assay, we show that both LXR and RXR ligands are sufficient to mediate cholesterol efflux in macrophage cells and their efficacy correlates with ABCA1 regulation. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 2 | Furthermore, by using a radiolabeled cholesterol efflux assay, we show that both LXR and RXR ligands are sufficient to mediate cholesterol efflux in macrophage cells and their efficacy correlates with ABCA1 regulation. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 3 | These studies strengthen further the notion that LXR and RXR mediate ABCA1 expression and cholesterol efflux in macrophage cells as a permissive heterodimer and development of small molecule ligands of these nuclear receptors may represent a promising approach to modulating cholesterol efflux and plasma HDL cholesterol level in humans. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 4 | These studies strengthen further the notion that LXR and RXR mediate ABCA1 expression and cholesterol efflux in macrophage cells as a permissive heterodimer and development of small molecule ligands of these nuclear receptors may represent a promising approach to modulating cholesterol efflux and plasma HDL cholesterol level in humans. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 5 | These studies strengthen further the notion that LXR and RXR mediate ABCA1 expression and cholesterol efflux in macrophage cells as a permissive heterodimer and development of small molecule ligands of these nuclear receptors may represent a promising approach to modulating cholesterol efflux and plasma HDL cholesterol level in humans. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |