Pub. Date : 2002 Oct 15
PMID : 12351406
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. | SU 5614 | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 2 | Both SU5416 and SU5614 were capable of inhibiting autophosphorylation of ITD and WT FLT3 (SU5416 concentration that inhibits 50% [IC(50)], 100 nM; and SU5614 IC(50) 10 nM). | SU 5614 | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 3 | FLT3 inhibition by SU5416 and SU5614 resulted in reduced proliferation (IC(50), 250 nM and 100 nM, respectively) and induction of apoptosis of FLT3 ITD-positive leukemic cell lines. | SU 5614 | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 4 | FLT3 inhibition by SU5416 and SU5614 resulted in reduced proliferation (IC(50), 250 nM and 100 nM, respectively) and induction of apoptosis of FLT3 ITD-positive leukemic cell lines. | SU 5614 | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 5 | We conclude that SU5416 and SU5614 are potent inhibitors of FLT3. | SU 5614 | fms related receptor tyrosine kinase 3 | Homo sapiens |