Pub. Date : 2002 Dec 1
PMID : 12325046
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SPECT studies 4, 10, and 31 days after MDMA treatment revealed decreases in [123I]beta-CIT binding ratios in the SERT-rich brain region studied (hypothalamic/midbrain region), with SERT density reduced by 39% in this brain region 31 days after treatment. | 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane | solute carrier family 6 member 4 | Rattus norvegicus |
| 2 | In addition, ex vivo [123I]beta-CIT binding studies in rats 1 week after treatment with neurotoxic doses of MDMA (20 mg/kg s.c. twice daily for 4 consecutive days) revealed significant reductions in [123I]beta-CIT binding in SERT-rich regions (including the hypothalamus) when compared to saline-treated rats. | 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane | solute carrier family 6 member 4 | Rattus norvegicus |
| 3 | The combined results of these studies indicate that SPECT imaging of SERT with [123I]beta-CIT can detect changes in SERT density secondary to MDMA-induced neurotoxicity in the hypothalamic/midbrain region, and possibly other brain regions. | 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane | solute carrier family 6 member 4 | Rattus norvegicus |
| 4 | The combined results of these studies indicate that SPECT imaging of SERT with [123I]beta-CIT can detect changes in SERT density secondary to MDMA-induced neurotoxicity in the hypothalamic/midbrain region, and possibly other brain regions. | 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane | solute carrier family 6 member 4 | Rattus norvegicus |