PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12325046-5	2002	SPECT studies 4, 10, and 31 days after MDMA treatment revealed decreases in [123I]beta-CIT binding ratios in the SERT-rich brain region studied (hypothalamic/midbrain region), with SERT density reduced by 39% in this brain region 31 days after treatment.	2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	82-90	solute carrier family 6 member 4	Rattus norvegicus	113-117	
12325046-7	2002	In addition, ex vivo [123I]beta-CIT binding studies in rats 1 week after treatment with neurotoxic doses of MDMA (20 mg/kg s.c. twice daily for 4 consecutive days) revealed significant reductions in [123I]beta-CIT binding in SERT-rich regions (including the hypothalamus) when compared to saline-treated rats.	2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	27-35	solute carrier family 6 member 4	Rattus norvegicus	225-229	
12325046-8	2002	The combined results of these studies indicate that SPECT imaging of SERT with [123I]beta-CIT can detect changes in SERT density secondary to MDMA-induced neurotoxicity in the hypothalamic/midbrain region, and possibly other brain regions.	2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	85-93	solute carrier family 6 member 4	Rattus norvegicus	69-73	
12325046-8	2002	The combined results of these studies indicate that SPECT imaging of SERT with [123I]beta-CIT can detect changes in SERT density secondary to MDMA-induced neurotoxicity in the hypothalamic/midbrain region, and possibly other brain regions.	2beta-carbomethoxy-3beta-(4-iodophenyl)tropane	85-93	solute carrier family 6 member 4	Rattus norvegicus	116-120