Title : N(G)-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: inhibition by angiotensin II type 1 receptor antagonism.

Pub. Date : 2002 Sep

PMID : 12198334






4 Functional Relationships(s)
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1 >L-NAME treatment increased ventricular atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) mRNA levels and immunoreactive BNP levels significantly. NG-Nitroarginine Methyl Ester natriuretic peptide A Rattus norvegicus
2 >L-NAME treatment increased ventricular atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) mRNA levels and immunoreactive BNP levels significantly. NG-Nitroarginine Methyl Ester natriuretic peptide A Rattus norvegicus
3 Losartan therapy decreased the >l-NAME-induced ventricular ANP gene expression by 69% (p < 0.05) and also reduced ventricular BNP mRNA levels so that it did not differ from control. NG-Nitroarginine Methyl Ester natriuretic peptide A Rattus norvegicus
4 Results suggest that >l-NAME-induced hypertension and the associated activation of ventricular ANP and BNP gene expression are, at least in part, mediated by angiotensin II, whereas the resistance vessel hypertrophy following nitric oxide synthase inhibition is angiotensin II independent. NG-Nitroarginine Methyl Ester natriuretic peptide A Rattus norvegicus