Title : Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94.

Pub. Date : 2002 Aug

PMID : 12177176






1 Functional Relationships(s)
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1 Evaluated in vitro, 264W94 dose-dependently inhibited sodium-dependent uptake of 10 micro M [(3)H]taurocholic acid (TC) by rat and monkey brush border membrane vesicles with IC(50)s of 0.24 micro M and 0.41 micro M, and had a competitive profile with K(i) of 0.2 micro M against TC in Chinese hamster ovary cells expressing human IBAT. Technetium solute carrier family 10 member 2 Homo sapiens