Pub. Date : 2002 Aug 16
PMID : 12172079
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: A possible inhibition of SREBP-1c-dependent genes by the protease inhibitor indinavir and its possible reversal by the lipid-lowering drug simvastatin were studied. | Indinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |
| 2 | METHODS: The effects of indinavir and simvastatin on the inhibition/activation of SREBP-1c-dependent genes were compared with the effects of indinavir and simvastatin on the inhibition/activation of SREBP-1c-independent genes. | Indinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |
| 3 | RESULTS: Indinavir inhibited the SREBP-1c-dependent genes encoding the lipoprotein lipase (103 nmol/l resulted in an inhibition of 12.4%; P = 0.0051) and the fatty acid synthase (103 nmol/l resulted in an inhibition of 30.3%; P = 0.036) in a dose-dependent fashion but not the SREBP-1c-independent gene encoding the low-density lipoprotein receptor. | Indinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |
| 4 | RESULTS: Indinavir inhibited the SREBP-1c-dependent genes encoding the lipoprotein lipase (103 nmol/l resulted in an inhibition of 12.4%; P = 0.0051) and the fatty acid synthase (103 nmol/l resulted in an inhibition of 30.3%; P = 0.036) in a dose-dependent fashion but not the SREBP-1c-independent gene encoding the low-density lipoprotein receptor. | Indinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |
| 5 | Simvastatin antagonized the indinavir-induced SREBP-1c-inhibition. | Indinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |
| 6 | CONCLUSIONS: Indinavir inhibits important effector genes of the SREBP-1c pathway, explaining major HAART-related adverse effects. | Indinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |