Protein Name sterol regulatory element binding transcription factor 1
Organism Homo sapiens
Gene ID 6720
Gene Symbol


UniProt P36956 (SRBP1_HUMAN), B3KR77 (B3KR77_HUMAN), A8MTU8 (A8MTU8_HUMAN)
Relationships Total Number of functionally related compound(s) : 451
Total Number of Articles : 852

sterol regulatory element binding transcription factor 1

Gene Summary

This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]

  • sterol regulatory element-binding protein 1
  • class D basic helix-loop-helix protein 1
  • HMD
Click to show/hide the synonyms