Pub. Date : 2002 Oct 18
PMID : 12171915
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We found that phenylethyl isothiocyanate (PEITC) was capable of inducing JNK activation and apoptosis in prostate cancer cell lines with distinct p53 statuses. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | We found that phenylethyl isothiocyanate (PEITC) was capable of inducing JNK activation and apoptosis in prostate cancer cell lines with distinct p53 statuses. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | PEITC induced JNK-mediated apoptotic signaling via a different pathway than that used by DNA-damaging agents, because genotoxicresistant LNCaP prostate cancer cells were equally sensitive to PEITC as parental LNCaP cells. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | The JNK dephosphorylation and inactivation rates were decreased in cells exposed to PEITC. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Taken together, our data suggest that PEITC activates JNK through suppression of JNK dephosphorylation and that PEITC may be an alternative therapeutic agent for cancers that are resistant to genotoxic agents. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Taken together, our data suggest that PEITC activates JNK through suppression of JNK dephosphorylation and that PEITC may be an alternative therapeutic agent for cancers that are resistant to genotoxic agents. | phenethyl isothiocyanate | mitogen-activated protein kinase 8 | Homo sapiens |