Title : A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer.

Pub. Date : 2002 Aug

PMID : 12171880






1 Functional Relationships(s)
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1 ISIS 3521 and ISIS 5132 are antisense phosphorothioate oligonucleotides that inhibit PKC-alpha and Raf-1 expression, respectively, and induce a broad spectrum of antiproliferative and antitumor effects in several human tumor cell lines. Phosphorothioate Oligonucleotides Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens