Title : Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3.

Pub. Date : 2002 Oct 21

PMID : 12161280






2 Functional Relationships(s)
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1 Here we report that satratoxin G-treated human leukemia HL-60 cells underwent apoptosis through the action of caspase-3 which was activated by both caspase-8 and caspase-9. satratoxin G caspase 9 Homo sapiens
2 Furthermore, satratoxin G caused a release of cytochrome c from mitochondria into the cytosol and increased the activity of caspase-9 against LEHD-AMC. satratoxin G caspase 9 Homo sapiens