Title : Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter.

Pub. Date : 2002 Aug 1

PMID : 12151556






2 Functional Relationships(s)
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1 To determine if there was a temporal correlation between the time when sertraline induced downregulation of the SERT and when marked alteration in SERT function occurred, clearance of locally applied 5-HT into the CA3 region of hippocampus was achieved using in vivo electrochemistry. Sertraline solute carrier family 6 member 4 Rattus norvegicus
2 After 4 or 10 d treatment with sertraline, SERT binding sites decreased very little (15-30%), and the chronoamperometric signals for serotonin in sertraline-treated rats were comparable with ones obtained in control animals. Sertraline solute carrier family 6 member 4 Rattus norvegicus