Pub. Date : 2002 Jul 23
PMID : 12114539
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. | gadd | interleukin 24 | Homo sapiens |
| 2 | mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. | gadd | interleukin 24 | Homo sapiens |
| 3 | Infection of melanoma cells, but not normal immortal melanocytes, with Ad.mda-7 induced a time- and dose-dependent increase in expression, mRNA and protein, of a family of growth arrest and DNA damage (GADD)-inducible genes, which correlated with induction of apoptosis. | gadd | interleukin 24 | Homo sapiens |
| 4 | In addition, SB203580 effectively inhibited Ad.mda-7-mediated induction of the GADD family of genes in a time- and dose-dependent manner, and it effectively blocked Ad.mda-7-mediated down-regulation of the antiapoptotic protein BCL-2. | gadd | interleukin 24 | Homo sapiens |
| 5 | In addition, SB203580 effectively inhibited Ad.mda-7-mediated induction of the GADD family of genes in a time- and dose-dependent manner, and it effectively blocked Ad.mda-7-mediated down-regulation of the antiapoptotic protein BCL-2. | gadd | interleukin 24 | Homo sapiens |
| 6 | Inhibition of GADD genes by an antisense approach either alone or in combination also effectively blocked Ad.mda-7-induced apoptosis in melanoma cells. | gadd | interleukin 24 | Homo sapiens |
| 7 | These results support the hypothesis that Ad.mda-7 mediates induction of the GADD family of genes by means of the p38 MAPK pathway, thereby resulting in the selective induction of apoptosis in human melanoma cells. | gadd | interleukin 24 | Homo sapiens |