Protein Name interleukin 24
Organism Homo sapiens
Gene ID 11009
Gene Symbol

IL24

UniProt Q13007 (IL24_HUMAN)
Relationships Total Number of functionally related compound(s) : 168
Total Number of Articles : 187
Description

interleukin 24

Gene Summary

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

synonyms
  • interleukin-24
  • IL-4-induced secreted protein
  • melanocyte-associated Mda-7
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Properties