Title : Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation.

Pub. Date : 2002 May 31

PMID : 12039800






3 Functional Relationships(s)
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1 Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
2 Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
3 Treatment with the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate reduced junctional conductance in cells expressing Cx43, Cx45, or both connexins, but it reduced the extent of neurobiotin transfer only in HeLa-Cx43(His)(6) and HeLa-Cx43(His)(6)/Cx45 cells but not in the HeLa-Cx45 cells. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens