Pub. Date : 2002 Apr 16
PMID : 11967149
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: We have identified a conserved TOR signaling (TOS) motif in the N terminus of all known S6 kinases and in the C terminus of the 4E-BPs that is crucial for phosphorylation and regulation S6K1 and 4E-BP1 activities. | tos | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | Deletion or mutations within the TOS motif significantly inhibit S6K1 activation and the phosphorylation of its hydrophobic motif, Thr389. | tos | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | Furthermore, only overexpression of S6K1 with an intact TOS motif prevents 4E-BP1 phosphorylation by a common mTOR-regulated modulator of S6K1 and 4E-BP1. | tos | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | CONCLUSIONS: S6K1 and 4E-BP1 contain a conserved five amino acid sequence (TOS motif) that is crucial for their regulation by the mTOR pathway. | tos | ribosomal protein S6 kinase B1 | Homo sapiens |