PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11967149-4	2002	RESULTS: We have identified a conserved TOR signaling (TOS) motif in the N terminus of all known S6 kinases and in the C terminus of the 4E-BPs that is crucial for phosphorylation and regulation S6K1 and 4E-BP1 activities.	tos	55-58	ribosomal protein S6 kinase B1	Homo sapiens	195-210	
11967149-5	2002	Deletion or mutations within the TOS motif significantly inhibit S6K1 activation and the phosphorylation of its hydrophobic motif, Thr389.	tos	33-36	ribosomal protein S6 kinase B1	Homo sapiens	65-69	
11967149-8	2002	Furthermore, only overexpression of S6K1 with an intact TOS motif prevents 4E-BP1 phosphorylation by a common mTOR-regulated modulator of S6K1 and 4E-BP1.	tos	56-59	ribosomal protein S6 kinase B1	Homo sapiens	36-40	
11967149-9	2002	CONCLUSIONS: S6K1 and 4E-BP1 contain a conserved five amino acid sequence (TOS motif) that is crucial for their regulation by the mTOR pathway.	tos	75-78	ribosomal protein S6 kinase B1	Homo sapiens	13-28