Pub. Date : 2002 May
PMID : 11956159
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further, both okadaic acid and peroxyvanadate attenuate cAMP-stimulated increases in endogenous hCYP17 mRNA expression and in hCYP17 promoter-reporter construct luciferase activity. | Cyclic AMP | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Adrenocorticotropin/cyclic adenosine 3",5"-monophosphate-mediated transcription of the human CYP17 gene in the adrenal cortex is dependent on phosphatase activity. | Cyclic AMP | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Using inhibitors of serine/threonine phosphatase activity (okadaic acid) and phosphotyrosine phosphatase activity (peroxyvanadate), we can inhibit the cAMP-inducible binding of the steroidogenic factor-1 (SF-1), p54(nrb)/NonO, and polypyrimidine tract-binding protein-associated splicing factor (PSF) complex required for regulation of transcription to the promoter of hCYP17. | Cyclic AMP | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | Further, both okadaic acid and peroxyvanadate attenuate cAMP-stimulated increases in endogenous hCYP17 mRNA expression and in hCYP17 promoter-reporter construct luciferase activity. | Cyclic AMP | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 5 | Our findings demonstrate that activation of protein phosphatase(s) is essential for cAMP-dependent transcription of hCYP17 in H295R cells and suggest a role for PKA in phosphatase activation, which leads to dephosphorylation of SF-1 and increased gene transcription. | Cyclic AMP | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |