Title : Severe interaction between ritonavir and acenocoumarol.

Pub. Date : 2002 Apr

PMID : 11918509






1 Functional Relationships(s)
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1 DISCUSSION: RTV is an inducer of the hepatic isoenzymes CYP1A2, CYP1A4, and CYP2C9/19 and leads to extensive metabolism of acenocoumarol that cannot be balanced by dose increases. Ritonavir cytochrome P450 family 1 subfamily A member 2 Homo sapiens