Pub. Date : 2002 Feb
PMID : 11913545
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Semiquantitative RT-PCR analysis revealed that, of the four major testicular steroidogenic enzymes, mRNA levels of cytochrome P450 side-chain cleavage and 17beta-hydroxysteroid dehydrogenase type-III were significantly reduced, and mRNA levels of cytochrome P450 17alpha-hydroxylase/ C17-20 lyase (P450c17) were reduced severely and significantly, by EB administration. | estradiol 3-benzoate | cytochrome P450, family 17, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | In addition, the P450c17 mRNA level in EB-treated rats was much lower than that in the testes of hypophysectomized rats, with the level in the latter being equal to that in control rats. | estradiol 3-benzoate | cytochrome P450, family 17, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | The results indicated, at least, that EB administration down-regulates P450c17 gene expression predominantly, resulting in the inhibition of testosterone production. | estradiol 3-benzoate | cytochrome P450, family 17, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | From the differences in the steroidogenic enzyme expressions between hypophysectomized and EB-treated rats, it was suggested that EB acts on the testis directly or indirectly though not via alteration of LH secretion and induces reduction of P450c17 mRNA level. | estradiol 3-benzoate | cytochrome P450, family 17, subfamily a, polypeptide 1 | Rattus norvegicus |