PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11913545-6	2002	Semiquantitative RT-PCR analysis revealed that, of the four major testicular steroidogenic enzymes, mRNA levels of cytochrome P450 side-chain cleavage and 17beta-hydroxysteroid dehydrogenase type-III were significantly reduced, and mRNA levels of cytochrome P450 17alpha-hydroxylase/ C17-20 lyase (P450c17) were reduced severely and significantly, by EB administration.	estradiol 3-benzoate	351-353	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	298-305	
11913545-8	2002	In addition, the P450c17 mRNA level in EB-treated rats was much lower than that in the testes of hypophysectomized rats, with the level in the latter being equal to that in control rats.	estradiol 3-benzoate	39-41	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	17-24	
11913545-10	2002	The results indicated, at least, that EB administration down-regulates P450c17 gene expression predominantly, resulting in the inhibition of testosterone production.	estradiol 3-benzoate	38-40	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	71-78	
11913545-11	2002	From the differences in the steroidogenic enzyme expressions between hypophysectomized and EB-treated rats, it was suggested that EB acts on the testis directly or indirectly though not via alteration of LH secretion and induces reduction of P450c17 mRNA level.	estradiol 3-benzoate	91-93	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	242-249