Protein Name cytochrome P450, family 17, subfamily a, polypeptide 1
Organism Rattus norvegicus
Gene ID 25146
Gene Symbol

Cyp17a1

UniProt P11715 (CP17A_RAT), A0A0G2JSR8 (A0A0G2JSR8_RAT)
Relationships Total Number of functionally related compound(s) : 145
Total Number of Articles : 179
Description

cytochrome P450, family 17, subfamily a, polypeptide 1

Gene Summary

Enables steroid 17-alpha-monooxygenase activity. Involved in several processes, including animal organ development; response to fungicide; and response to herbicide. Located in cell projection; endoplasmic reticulum; and neuronal cell body. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • steroid 17-alpha-hydroxylase/17,20 lyase
  • 17-alpha-hydroxyprogesterone aldolase
  • CYPXVII
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Properties