Title : Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.

Pub. Date : 2002 Mar 1

PMID : 11911841






1 Functional Relationships(s)
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1 Among the metabolic reactions studied, diclofenac 4-hydroxylation (DFH), dextromethorphan O-demethylation (DMOD) and midazolam 4-hydroxylation were specifically catalyzed by CYP2C6, CYP2D2 and CYP3A1/3A2, respectively. Dextromethorphan cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus