Title : Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries.

Pub. Date : 2002 Mar

PMID : 11790724






1 Functional Relationships(s)
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1 Inhibition of alpha4beta2, either pharmacological (i.e., an alpha4beta2 nAChR antagonist) or molecular (beta2-/- knockout mice), abolished the protective effect of nicotine in vivo and in vitro, suggesting the involvement of alpha4beta2 nAChR in neonatal nicotine-related neuroprotection. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus