Title : Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response.

Pub. Date : 2002 Jan 18

PMID : 11707454






1 Functional Relationships(s)
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1 Incubation of HepG2 human hepatoma cells in glucose-free medium resulted in an increased HO-1 mRNA content, reaching a maximum of approximately 25-fold over control cells after 12 h. The glucose-dependent induction of HO-1 mRNA was concentration-dependent (k(12) approximately 0.5 mm) and was attenuated by fructose, galactose, mannose, and 2-deoxyglucose, but not by the non-metabolizable glucose analog, 3-O-methylglucose. 3-O-Methylglucose heme oxygenase 1 Homo sapiens