Title : Ganglioside GM3 participates in the pathological conditions of insulin resistance.

Pub. Date : 2002 Feb 1

PMID : 11707432






1 Functional Relationships(s)
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1 Pharmacological depletion of GM3 in adipocytes by an inhibitor of glucosylceramide synthase prevented the TNF-alpha-induced defect in insulin-dependent tyrosine phosphorylation of IRS-1 and also counteracted the TNF-alpha-induced serine phosphorylation of IRS-1. Tyrosine tumor necrosis factor Rattus norvegicus