Pub. Date : 2001 Oct
PMID : 11683901
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have reported that the development of morphine tolerance significantly increased calcitonin-gene-related-peptide-like immunoreactivity (CGRP-IR) in primary sensory afferents of the spinal dorsal horn, suggesting that changes in pain-related neuropeptides in the dorsal root ganglion (DRG) neurons may be involved (Menard et al., 1996, J. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
2 | Recently, we have shown that repeated morphine treatments induced increases in CGRP- and substance P (SP)-IR in cultured DRG, mimicking the in vivo effects (Ma et al., 2000, Neuroscience, 99, 529-539). | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
3 | In this study, we investigated the intracellular signal transduction pathways possibly involved in morphine-induced increases in CGRP- and SP-IR in DRG neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
4 | Naloxone effectively blocked these actions of morphine, whereas a selective MEK1 inhibitor, PD98059, inhibited the morphine-induced increase in the phosphorylation of ERK and CREB, and the expression of CGRP and SP. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
5 | Naloxone effectively blocked these actions of morphine, whereas a selective MEK1 inhibitor, PD98059, inhibited the morphine-induced increase in the phosphorylation of ERK and CREB, and the expression of CGRP and SP. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
6 | Moreover, in morphine-tolerant rats, the number of pCREB-, CGRP- and SP-IR neurons in the lumbar DRG was also significantly increased. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
7 | These in vitro and in vivo data suggest that the phosphorylation of MAP kinases and CREB plays a role in the morphine-induced increase in spinal CGRP and SP levels in primary sensory afferents, contributing to the development of tolerance to opioid-induced analgesia. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |