PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11683901-3	2001	We have reported that the development of morphine tolerance significantly increased calcitonin-gene-related-peptide-like immunoreactivity (CGRP-IR) in primary sensory afferents of the spinal dorsal horn, suggesting that changes in pain-related neuropeptides in the dorsal root ganglion (DRG) neurons may be involved (Menard et al., 1996, J.	Morphine	41-49	calcitonin-related polypeptide alpha	Rattus norvegicus	139-143	
11683901-5	2001	Recently, we have shown that repeated morphine treatments induced increases in CGRP- and substance P (SP)-IR in cultured DRG, mimicking the in vivo effects (Ma et al., 2000, Neuroscience, 99, 529-539).	Morphine	38-46	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83	
11683901-6	2001	In this study, we investigated the intracellular signal transduction pathways possibly involved in morphine-induced increases in CGRP- and SP-IR in DRG neurons.	Morphine	99-107	calcitonin-related polypeptide alpha	Rattus norvegicus	129-144	
11683901-10	2001	Naloxone effectively blocked these actions of morphine, whereas a selective MEK1 inhibitor, PD98059, inhibited the morphine-induced increase in the phosphorylation of ERK and CREB, and the expression of CGRP and SP.	Morphine	46-54	calcitonin-related polypeptide alpha	Rattus norvegicus	203-207	
11683901-10	2001	Naloxone effectively blocked these actions of morphine, whereas a selective MEK1 inhibitor, PD98059, inhibited the morphine-induced increase in the phosphorylation of ERK and CREB, and the expression of CGRP and SP.	Morphine	115-123	calcitonin-related polypeptide alpha	Rattus norvegicus	203-207	
11683901-11	2001	Moreover, in morphine-tolerant rats, the number of pCREB-, CGRP- and SP-IR neurons in the lumbar DRG was also significantly increased.	Morphine	13-21	calcitonin-related polypeptide alpha	Rattus norvegicus	59-74	
11683901-12	2001	These in vitro and in vivo data suggest that the phosphorylation of MAP kinases and CREB plays a role in the morphine-induced increase in spinal CGRP and SP levels in primary sensory afferents, contributing to the development of tolerance to opioid-induced analgesia.	Morphine	109-117	calcitonin-related polypeptide alpha	Rattus norvegicus	145-149