Title : Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF. evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by CDC42-GTP.

Pub. Date : 2001 Jun 15

PMID : 11285260






5 Functional Relationships(s)
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1 Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF. Guanosine Diphosphate cell division cycle 42 Homo sapiens
2 Here, we report that retaining Cdc42 in its GDP-bound state by overexpressing Rho-GDI inhibits Ras-GRF-mediated MAPK activation. Guanosine Diphosphate cell division cycle 42 Homo sapiens
3 In contrast, promoting GDP release from Cdc42 with the Rho family GEF Dbl or with ionomycin suppressed the restraint exerted by Cdc42 on Ras-GRF activity. Guanosine Diphosphate cell division cycle 42 Homo sapiens
4 In contrast, promoting GDP release from Cdc42 with the Rho family GEF Dbl or with ionomycin suppressed the restraint exerted by Cdc42 on Ras-GRF activity. Guanosine Diphosphate cell division cycle 42 Homo sapiens
5 Interestingly, the loss of the GDP-bound state by Cdc42 abolishes its inhibitory effects on Ras-GRF function. Guanosine Diphosphate cell division cycle 42 Homo sapiens