Pub. Date : 1999 Summer
PMID : 11228747
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, we have shown that ROS (hydrogen peroxide, fatty acid hydroperoxide, diperoxovanadate, and 4-hydroxynonenal) enhance protein tyrosine phosphorylation and activate phospholipase D (PLD) in bovine pulmonary artery endothelial cells (BPAECs). | Reactive Oxygen Species | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 2 | In the present study, our aim was to investigate the role of exogenous thiol agents on ROS-induced PLD activation in conjunction with the role of cellular thiols--glutathione (GSH) and protein thiols--on PLD activation and protein tyrosine phosphorylation. | Reactive Oxygen Species | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 3 | Pretreatment of BPAECs with N-acetyl-L-cysteine (NAC) or 2-mercaptopropionylglycine (MPG) blocked ROS-induced changes in intracellular GSH and PLD activation. | Reactive Oxygen Species | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 4 | These results support the hypothesis that modulation of thiol-redox status (cellular nonprotein and protein thiols) may contribute to the regulation of ROS-induced protein tyrosine phosphorylation and PLD activation in vascular endothelium. | Reactive Oxygen Species | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |